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Abstract #4082

Normalization of Magnetization Transfer Ratio MRI for Multicentre Clinical Trials

Robert Allan Brown1, Sridar Narayanan1, Harold Atkins2, Mark S. Freedman3, Douglas L. Arnold1

1Montreal Neurological Institute, McGill University, Montreal, QC, Canada; 2Division of Hematology, Ottawa Hospital Regional Cancer Centre, Ottawa, ON, Canada; 3Department of Medicine (Neurology), the Ottawa Hospital, Ottawa, ON, Canada

Magnetization transfer ratio MRI is a promising technique for measuring in vivo demyelination and remyelination. However, MTR values are scanner and sequence dependent. We propose a normalization technique, based on imaging of a normal control, that maps MTR values to a semi-quantitative scale that is comparable across sites in multicentre trials and between studies. The performance of this technique is compared to an alternative, statistically based technique proposed in the literature.