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Abstract #4086

Brain Atlas-Based Lesion Spatial Distribution & Modeling of Wallerian Degeneration in Multiple Sclerosis

Khader M. Hasan1, Indika S. Walimuni1, Sushmita Datta1, Flavia Nelson2, Jerry S. Wolinsky3, Ponnada A. Narayana4

1Radiology, UTHSCH, Houston, TX, United States; 2Neurology, UTHSCH, Houston, TX; 3Neurology, UTHSCH, Houston, Texasa, United States; 4Radiology, UTHSCH, Houston, Uexasa, United States

In this work, we describe a computational framework that provides human brain atlas-based regional lesion volume, NAWM and NAGM volumetry and their corresponding microstructural qMRI metrics (e.g. relaxation, anisotropy, axial, radial and mean diffusivities). We applied our methods to provide lesion distribution maps of a cohort of relapsing remitting (RR) MS patients relative to anatomical labels of deep GM nuclei, cortical GM matter parcellation and white matter tracts provided by the international consortium for brain mapping (ICBM) and Freesurfer. We demonstrate the importance of lesion volume distribution and proximity to explain disability in MS.