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Abstract #4125

Varying Resting-State Brain Activity in the "default-Mode Network" in Post-Stroke Aphasia

Quan Zhang1, Li Sang1, Ming Song2, Yunting Zhang1, Tianzi Jiang2

1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China, People's Republic of; 2National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences

Fifteen patients with expressive aphasia after cerebral infarction and 15 normal subjects were selected to investigate the changes of intrinsically organized default mode network (DMN) with the resting fMRI. Functional connectivity among 13 regions in DMN was computed with the Pearsons correlation analysis. As compared to the controls, most nodes within the DMN exhibited reduced functional connectivity in aphasic patients. The only one pair of medial prefrontal cortex (anterior) and cerebellar tonsils showed increased functional connectivity in patients. Our findings suggest that the varying functional connectivity in DMN in aphasia may be brain reorganization secondary to the ischemic damage.