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Abstract #4147

Impaired fMRI Activation in Patients with Primary Brain Tumors

Zhen Jiang1,2, Alexandre Krainik1,3, Olivier David3, Dominique Hoffmann1, Irene Tropres4, Sylvie Grand1,3, Emmanuel Barbier3, Stephan Chabardes1,3, Jan Warnking3, Jean-Francois Le Bas1,3

1University Hospital Grenoble, Grenoble, France; 22nd Affiliated Hospital - Soochow University, Suzhou, China, People's Republic of; 3Grenoble Institute of Neurosciences, Grenoble, France; 4Joseph Fourier University, Grenoble, France

In patients with brain tumor, motor-related activation in primary sensorimotor cortex was decreased in the ipsitumoral hemisphere, in case of meningiomas and high grade gliomas, but not in low grade gliomas. It was related to the vicinity of the lesion. Changes in basal perfusion did not account for the variance of activation asymmetry. BOLD signal evaluated using carbogen inhalation, a gas mixture of CO2 (7%) and O2 (93%), showed a similar asymmetry in eloquent cortices. Decreased interhemispheric ratio of the BOLD response to carbogen was the best predictor of the asymmetry of motor activation.