Abstract #4150

Resting State Functional Connectivity Changes with Subthalamic Nucleus Deep Brain Stimulation in a Parkinson's Disease Patient

Jenny Wu^1,2, Erik B. Beall¹, Mark J. Lowe¹, Benjamin L. Walter^3,4, Andre Machado⁵, Micheal D. Phillips¹

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States; ²New York Medical College, Valhalla, NY, United States; ³Neurological Institute, University Hospitals Case Medical Center, Cleveland, OH, United States; ⁴Case Western Reserve University School of Medicine, Cleveland, OH, United States; ⁵Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States

This study compared resting state functional connectivity in a Parkinson's Disease (PD) patient between on and off subthalamic nucleus deep brain stimulation (STN-DBS) conditions. MPRAGE and resting state fMRI studies were acquired from a unilateral STN-DBS PD patient. Seed-based correlation analyses using basal ganglia regions of interest generated z-score maps of significant correlation to each region. Stimulation decreased bilateral connectivity in putamen and globus pallidus but increased thalamic connectivity with supplementary motor areas. These stimulation-associated changes may be involved with desynchronization of pallidal output to thalamus leading to strengthened connectivity to cortical areas.