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Abstract #4168

Slow Fluctuation BOLD Signal Component Analysis During Active Press Pain Stimulation in Fibromyalgia Patients

Ji-Young Kim1, Jeehye Seo2, Jae-Jun Lee2, Hui-Jin Song2, Seong-Uk Jin2, Yongmin Chang2,3

1School of Medicine, Kyungpook Nataional University, Daegu, Korea, Republic of; 2Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of; 3Diagnostic Radiology, Kyungpook National University, Daegu, Korea, Republic of

Fibromyalgia is a medical disorder characterized by chronic widespread pain, a heightened and painful response to pressure. Currently no investigation is available for identifying low frequency BOLD fluctuation components during active press pain stimulation paradigm while recent study evaluated low frequency fluctuation during resting-state. Using independent components analysis (ICA) of active press pain paradigm, our results demonstrated (1) the existence of intrinsic slow fluctuation BOLD signal components during active pain stimulation paradigm and (2) the possible differences in intrinsic brain connectivity between FM patients and healthy controls.