Abstract #4175

Dynamics of Cerebral Glucose Analysed In Vivo with a Four-State Conformational Model

Joao M. N. Duarte^1,2, Rolf Gruetter^1,3

¹Laboratory for Functional & Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique, Lausanne, Vaud, Switzerland; ²Faculty of Biology & Medicine, University of Lausanne, Lausanne, Vaud, Switzerland; ³Department of Radiology, Universities of Lausanne & Geneva, Switzerland

Glucose is the primary fuel required for brain function. We now evaluated brain glucose dynamics by employing a four-state conformational model that accounts for transport inhibition, and a dynamic method that allows distinguishing the parameters defining transport from comsumption.