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Abstract #4177

Metabolic Changes in the Focal Brain Ischemia in Rats Treated with Human Induced Pluripotent Cell-Derived Neural Precursors

Daniel Jirak1,2, Karolina Turnovcova3, Nataliya Kozubenko3, Pavla Jendelova3, Milan Hajek1,2

1Department of Diagnostic & Interventional Radiology, Institute for Clinical & Experimental Medicine, Prague, Czech Republic; 2Center for Cell Therapy & Tissue Repair, Prague, Czech Republic; 3Institute of Experimental Medicine, Czech Republic

We describe the use of human-induced pluripotent cell-derived neural progenitors for transplantation into the rat brain after temporary middle cerebral artery occlusion. The aim of our study was to determine metabolic changes by 1H MR spectroscopy in the striatal tissue after focal brain ischemia during four months.