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Abstract #4182

The Influence of Physical Activity on the Structure & Metabolism of the Mouse Hippocampus - Combining 1H MRS & VBM at 9.4T

Wolfgang Weber-Fahr1, Sarah Biedermann1, Lei Zheng1,2, Claudia Falfn-Melgoza1, Johannes Fuss3, Alexander Sartorius3, Peter Gass3, Gabriele Ende1

1Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2Experimental Radiation Oncology, , University Medical Center Mannheim, Mannheim, Germany; 3Psychiatry, Central Institute of Mental Health, Mannheim, Germany

Voluntary wheel running in mice is known to effectively increase hippocampal neurogenesis within weeks. We assessed metabolic and structural profiles of the right hippocampus in two groups of mice which differed by their access to wheel running, using in vivo 1H MRS and Voxel-Based Morphometry (VBM) with a cryogenic mouse-brain coil. The MRS findings show a significant decrease of Glutamate in the right hippocampus of the sport-group. The VBM over the whole brain revealed a significant cluster of increased grey matter in the right hippocampus and a negative correlation between Glutamate and volume in the same region.