Shiyang Wang1,2, Michael Chopp1,2,
Guangliang Ding1, Mohammad-Reza Nazem-Zadeh1, Siamak
Pourabdollah Nejad D.1, Changsheng Qu3, Zhenggang Zhang1,
Asim Mahmood3, Lian Li1, Li Zhang1, Quan
Jiang1,2
1Neurology, Henry Ford
Health System, Detroit, MI, United States; 2Physics, Oakland University,
Rochester, MI, United States; 3Neurosurgery, Henry Ford Health
System, Detroit, MI, United States
We investigated neurite remodeling after cell-based treatment of traumatic brain injury (TBI) using MRI neurite density imaging and gold standard immuno-histochemistry staining. We demonstrate that MRI measured neurite densities are highly correlated with immuno-histochemistry measurements and MRI neurite densities provide a marker for brain structure remodeling after TBI.