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Abstract #4199

Diffusion Spectrum Imaging After Stroke Shows Structural Changes in the Contra-Lateral Motor Network Correlating with Functional Recovery.

Cristina Granziera1,2, Alessandro Daducci3, Xavier Gigandet3, Leila Cammoun3, Meskaldji Eddine Djalel3, Patrik Michel1, Philippe Maeder4, Alma Gregory Sorensen5, Jean-Philippe Thiran3, Reto Meuli4, Gunnar Krueger6

1Neurology, CHUV, Lausanne, VD, Switzerland; 2BMI, EPFL, Lausanne, VD, Switzerland; 3STI / IEL / LTS5, EPFL, Lausanne, VD, Switzerland; 4Radiology, CHUV, Lausanne, VD, Switzerland; 5Radiology, Martinos' Center-MGH, Boston, MA, United States; 6Healthcare Sector IM&WS S, Siemens Schweiz AG, Renens, VD, Switzerland

There is growing interest in the role of the contra-lateral hemisphere in stroke recovery. To determine the importance of the contra-lateral structural changes in post-stroke motor recovery, we studied with Diffusion Spectrum Imaging MRI a cohort of patients with motor deficits after stroke affecting the motor cortex and/or sub-cortical motor white matter. Changes in Generalized Fractional Anisotropy in patients significantly differed from GFA changes in controls, correlated with patients clinical scores, stroke size and demographics data and could be modeled through these variables in the majority of investigated motor connections. These findings may become particular interesting for outcome prediction and post-stroke rehabilitation.