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Abstract #4211

Serial Diffusion Tensor Imaging Suggests Progressive Pathophysiology for Weeks Following Traumatic Brain Injury, & Possible White Matter Repair Months After Injury

Virginia Newcombe1, Guy Williams2, Joanne Outtrim1, Doris Chatfield1, M. G. Abate1, T. Geeraerts1, A. Manktelow1, Peter Hutchinson3, Jonathon Coles1, David Menon1

1Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Wolfson Brain Imaging Centre, Univerisity of Cambridge; 3Academic Department of Neurosurgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. It is clear that much of the sequelae are not just a direct consequence of the acute event represent a dynamic process with changes occurring many years after the precipitating injury. In this study, a consistent pattern was found of FA being low immediately post injury. It appears to worsen for several weeks, with a nadir at approximately six months. When patients are followed up past the six month time point there appears to be an increase in FA, which may indicate recovery.