Virginia Newcombe1, Guy Williams2,
1Division of Anaesthesia, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Wolfson Brain Imaging Centre, Univerisity of Cambridge; 3Academic Department of Neurosurgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. It is clear that much of the sequelae are not just a direct consequence of the acute event represent a dynamic process with changes occurring many years after the precipitating injury. In this study, a consistent pattern was found of FA being low immediately post injury. It appears to worsen for several weeks, with a nadir at approximately six months. When patients are followed up past the six month time point there appears to be an increase in FA, which may indicate recovery.