Giovanni Rizzo1, David Neil Manners1, Caterina Tonon1, Claudia Testa1, Emil Malucelli1, Maria Lucia Valentino2, Chiara La Morgia2, Piero Barboni2, Bruno Barbiroli1, Valerio Carelli2, Raffaele Lodi1
1Department of Internal Medicine, Aging & Nephrology, University of Bologna, Bologna, Italy; 2Department of Neurological Sciences,, University of Bologna, Bologna, Italy
Objectives. To use DWI to investigate the optic radiation in LHON patients and healthy carriers. Methods. MD maps from 22 LHON patients, 11 healthy carriers and 22 healthy controls were generated. ROIs at level of optic radiations were delineated. Results. OR MD values of patients were higher than in healthy carriers and healthy controls. Increased diffusivity was associated with both a history of lack of recovery of visual acuity and disease duration. Conclusions. We confirmed a retrochiasmatic involvement in LHON patients, which seems to be a secondary phenomenon, reflecting a downstream rather than a primary effect of the mitochondrial dysfunction.