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Abstract #4220

Longitudinal Assessment of Chemotherapy-Induced Structural Changes in Cerebral White Matter & Its Correlation with Impaired Cognitive Functioning in Breast Cancer Patients

Sabine Deprez1, Frederic Amant2, Judith Verhoeven1, Ann Smeets2, Marie-Rose Christiaens2, Alexander Leemans3, Ron Peeters1, Wim Van Hecke1, Joris Vandenberghe4, Mathieu Vandenbulcke4, Stefan Sunaert1

1Department of Radiology, University Hospital Gasthuisberg, K.U. Leuven, Leuven, Belgium; 2Multidisciplinary Breast Center, University Hospital Gasthuisberg, K.U. Leuven; 3Image Sciences Institute, Department of Radiology, University Medical Center Utrecht; 4Department of Psychiatry, University Hospital Gasthuisberg, K.U. Leuven

Cognitive impairment is a potential adverse effect of systemic cancer treatment. In this longitudinal DTI study we assessed breast-cancer patients (n=34) before and after chemotherapy and evaluated possible changes in WM FA in combination with cognitive assessment. Voxel-based paired T-test revealed significantly decreased FA after treatment in frontal, parietal and occipital WM tracts, while this effect was not present in control groups assessed at matched intervals (non-chemotherapy-treated patients (n=16) and healthy-controls (n=19)). Significant correlations between differences in FA and differences in attention and verbal memory scores were found. These results suggest a link between WM integrity and treatment-induced impaired cognition.