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Abstract #4227

FA & Tract Changes in Obsessive Compulsive Disorder

An Vo1, Patricia Gruner1,2, Toshikazu Ikuta1,2, Katie Mahon1,2, Vivian Kafantaris1,2, Juan Gallego1,2, Katherine E. Burdick1,2, Aziz M. Ulug1,3, Philip R. Szeszko1,2

1The Feinstein Institute for Medical Research, Manhasset, NY, United States; 2The Zucker Hillside Hospital, Glen Oaks, NY, United States; 3Department of Radiology, Albert Einstein School of Medicine, Bronx, NY, United States

Obsessive-compulsive disorder (OCD) is an anxiety disorder and is characterized by recurrent, unwanted thoughts and/or repetitive behaviors. It has been hypothesized that some forms of OCD are a result of disinhibition in the cortico-striato-thalamocortical circuitry and the lesions in the anterior cingulate cortex might contribute. The purpose of this study is to use DTI derived metrics to explore disease affected circuits in OCD patients.