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Abstract #4265

Prognostic Imaging Markers in Patients with GBM: Comparison between Functional Versus Mean KPS Analysis

Andrea Kassner1, Igor Sitartchouk1, Fang Liu2, Jeremy Hoisak3, Adam Gladwish3, Normand Laperriere3, Cynthia Menard3

1Medical Imaging, University of Toronto, Toronto, Ontario, Canada; 2Diagnostic Imaging, Hospital for Sick Children, Toronto; 3Radiation Oncology, University of Toronto, Toronto

Glioblastoma multiforme (GBM) is the most common primary brain tumor and has a very poor prognosis. Treatment assessment is difficult as early imaging changes cannot be easily differentiated from tumor progression (i.e. pseudo early progression). We used DCE-MRI to obtain coefficients of permeability estimates (KPS) from 25 GBM patients at three different timepoints (baseline, during radiotherapy, post radiotherapy) and found that mean KPS of pseudo early progressors was signifcantly greater than in early progressors (EPs)during radiotherapy and shows a potential for discrimination EPs from pseudo EPs.