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Abstract #4299

Evidence of Wallerian Degeneration in the Human Spinal Cord using In Vivo High-Resolution DTI & Magnetization Transfer

Julien Cohen-Adad1,2, Bradley Buchbinder2,3, Lawrence L. Wald1,4, Anne Louise Oaklander2,3

1A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 2Harvard Medical School, Boston, MA, United States; 3Massachusetts General Hospital, Boston, MA, United States; 4Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States

We combined high resolution diffusion-weighted, magnetization transfer and conventional MRI of the spinal cord in a patient with focal cervical cord injury (SCI). Concomitant analysis of images suggested anterograde Wallerian degeneration in the dorsal left pathway. The correlation between DW and MT measurements and the neurological abnormalities provides incentive to perform multi-parametric spinal MRI to better distinguish demyelination and degeneration after SCI.