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Abstract #4341

New Insight Into Mechanism of Epileptogenesis with Dynamic T1 Contrast Perfusion MRI in Calcified Neurocysticercosis

Rakesh Kumar Gupta1, Rishi Awasthi1, Prativa Sahoo2, Avantika Verma3, Vimal Kumar Paliwal4, Ramesh Venkatesan5, Kashi Nath Prasad3, Ram K. S. Rathore2

1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; 3Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 4Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 5Wipro-GE Healthcare, Bangalore, Karnataka, India


DCE-MRI was performed on 30 patients with Neurocysticercosis (NCC), cysts which were found to be calcified on imaging. Various perfusion indices were analyzed and it was found that Kep, ve and MMP-9 expression were significantly higher in symptomatic as compared to asymptomatic patients. Moreover, a strong correlation of serum MMP-9 with Kep portend that Kep can be used to differentiate between symptomatic and asymptomatic patients.