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Abstract #4344

Effects of Prenatal Cocaine Exposure on Human Brain Structures

Xiangchuan Chen1, Claire D. Coles2, Mary E. Lynch2, Zhihao Li1, Xiaoping Hu1

1Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States; 2Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA, United States

Investigation of brain structural outcomes induced by prenatal cocaine exposure (PCE) was performed by automatically segmenting the cerebral cortex and sub-cortical structures into various regions of interest (ROIs) with Freesurfer on T1-weighted images. No significant PCE effect was found on the volumes of sub-cortical ROIs. In contrast, the entire left and right cerebral cortices and a few cortical ROIs exhibited reduced volume by PCE. In addition, a gender difference in PCE effect was found, suggesting that female may be more vulnerable to PCE than male. Thus, the gender factor should be considered in future studies in this field.