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Abstract #4349

Correlating Functional & Structural Connectivity of Default Mode Network with Dosage of Two Candidate Vulnerability Genes of Schizophrenia

Su-Chun Huang1,2, Chih-Min Liu3, Hai-Go Hwu3, Chen-Chung Liu3, Fa-Hsuan Lin1, Wen-Yih Isaac Tseng1,2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 3Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan

With the combined resting-state fMRI and diffusion spectrum imaging, the relationships were investigated between functional connectivity (FC), structural connectivity (SC) of the default mode network (DMN) and the dosage of candidate vulnerability genes (NRG1 and DISC1). Significant correlations were found between the gene dosage and FCs in two pairs of the DMN, i.e. the right medial frontalleft inferior parietal pair and the right inferior parietalright posterior cingulate cortex pair. Further, a significant correlation was found between the gene dosage and SC of bilateral posterior cingulate cortices. No significant correlation was found between the gene dosage and PANSS. Our results suggest that the gene dosage might influence FC and SC of the DMN, but not directly reflect clinical symptoms.