Su-Chun Huang1,2, Chih-Min Liu3,
Hai-Go Hwu3, Chen-Chung Liu3, Fa-Hsuan Lin1,
Wen-Yih Isaac Tseng1,2
1Institute of Biomedical
Engineering, National Taiwan University, Taipei, Taiwan; 2Center
for Optoelectronic Biomedicine, National Taiwan University College of
Medicine, Taipei, Taiwan; 3Department of Psychiatry, National
Taiwan University Hospital, Taipei, Taiwan
With the combined resting-state fMRI and diffusion spectrum imaging, the relationships were investigated between functional connectivity (FC), structural connectivity (SC) of the default mode network (DMN) and the dosage of candidate vulnerability genes (NRG1 and DISC1). Significant correlations were found between the gene dosage and FCs in two pairs of the DMN, i.e. the right medial frontalleft inferior parietal pair and the right inferior parietalright posterior cingulate cortex pair. Further, a significant correlation was found between the gene dosage and SC of bilateral posterior cingulate cortices. No significant correlation was found between the gene dosage and PANSS. Our results suggest that the gene dosage might influence FC and SC of the DMN, but not directly reflect clinical symptoms.
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