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Abstract #4352

γ-Aminobutyric Acid (GABA) Modulates Functional Connectivity Network Strength in Adolescent Major Depressive Disorder

Vilma Gabbay1, Benjamin Ely1, Soraja Bangaru1, Michael Milham1, Xiangling Mao2, Francisco X. Castellanos1, Dikoma C. Shungu2

1Child Study Center, New York University School of Medicine, New York, NY, United States; 2Radiology, Weill Cornell Medical College, New York, NY, United States

This study aimed to examine the relationship between striatal functional connectivity (FC) and anterior cingulate cortex (ACC) GABA concentrations in adolescents with MDD and healthy controls. It was hypothesized that the ACC GABAergic system modulates fronto-striatal connectivity, and that this modulation is disrupted in adolescents with MDD.