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Abstract #4354

Measurement of Cerebral Metabolic Rate of Oxygen (CMRO2) using QBOLD Technique in Resting State

Xiang He1, Dmitriy A. Yablonskiy2, Kyongtae Ty Bae1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2Mallinckrodt Institute of Radiology, Washington Uninversity in St Louis, St Louis, MO, United States

MRI-based quantitative BOLD (qBOLD) method allows for non-invasive regional measurement of OEF. In this study, we have developed and implemented an ASL-qBOLD technique to determine quantitative in vivo absolute CMRO2 maps of the brain in the human brain in the resting state. We demonstrated that imaging artifacts can be effectively minimized by incorporating techniques such as over-sampling and navigator echoes. In addition, high SNR in blood flow measurement can be achieved by averaging the perfusion MR signal along the qBOLD echo train. Application of these methods facilitates a robust estimation of absolute CMRO2 in the brain baseline state.