Xiang He1, Dmitriy A. Yablonskiy2,
Kyongtae Ty Bae1
1Department of Radiology,
University of Pittsburgh, Pittsburgh, PA, United States; 2Mallinckrodt
Institute of Radiology, Washington Uninversity in St Louis, St Louis, MO,
United States
MRI-based quantitative BOLD (qBOLD) method allows for non-invasive regional measurement of OEF. In this study, we have developed and implemented an ASL-qBOLD technique to determine quantitative in vivo absolute CMRO2 maps of the brain in the human brain in the resting state. We demonstrated that imaging artifacts can be effectively minimized by incorporating techniques such as over-sampling and navigator echoes. In addition, high SNR in blood flow measurement can be achieved by averaging the perfusion MR signal along the qBOLD echo train. Application of these methods facilitates a robust estimation of absolute CMRO2 in the brain baseline state.