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Abstract #4450

Quantitative Magnetic Resonance Imaging in Light-Chain (AL) Amyloidosis: Preliminary Experience

Stephan William Anderson1, Jennifer Ellis-Ward2, Erskine Hawkins3, James A. Hamilton4, Carl J. O'Hara5, Lawreen H. Connors6, Jorge A. Soto1, David C. Seldin2, Hernan Jara1

1Radiology, Boston University Medical Center, Boston, MA, United States; 2Hematology & Medical Oncology, Boston University Medical Center; 3Boston University School of Medicine; 4Physiology & Biophysics, Boston University Medical Center; 5Pathology & Laboratory Medicine, Boston University Medical Center; 6Biochemistry, Boston University School of Medicine

Purpose: To evaluate the effects of amyloid deposition on T2 and apparent diffusion coefficient (ADC) measurements in human autopsy specimens of myocardium, liver, spleen, and kidney of patients with AL amyloidosis using 11.7T MRI.