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Abstract #4454

Accurate T1 Measurement with IR-Prepared Segmented Gradient Echo & a New Regression Algorithm

Haosen Zhang1, Kevin Hitchens1, Qing Ye1, Erik B. Schelbert2, Chien Ho1

1Pittsburgh NMR Center for Biomedical Research, Department of Biological Science, Carnegie Mellon University, Pittsburgh, PA, United States; 2Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States

In this study, an inversion recovery (IR)-prepared segmented gradient echo sequence was developed to sample the T1 recovery curve in Look-Locker scheme at 7 T. Via a multi-variable regression algorithm corrected for the saturation effect induced by the -train, we have obtained more accurate T1 values than with the conventional three-parameter fit (average error of -0.53% vs. -5.4% separately, compared to T1s measured with IR-SE) in agarose phantoms simulating human myocardium and blood.