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Abstract #4456

Fast Radio-Frequency Enforced Steady State (FRESS) Spin Echo MRI for Quantitative T2 Mapping

Jerry S. Cheung1, Enfeng Wang1,2, XiaoAn Zhang2, Emiri Mandeville3, Eng H. Lo3, A. Gregory Sorensen1, Phillip Zhe Sun1

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH & Harvard Medical School, Charlestown, MA 02129, United States; 2Department of Radiology, 3rd Affiliated Hospital, Zhengzhou University, China, People's Republic of; 3Neuroprotection Research Laboratory, Department of Radiology & Neurology, MGH and Harvard Medical School, Charlestown, MA 02129, United States

Transverse relaxation time (T2) is a basic but very informative MRI parameter, widely used in imaging to examine a host of diseases including multiple sclerosis, stroke, and tumor. When the repetition time (TR) is very long, T2 can be derived by fitting T2-weighted images as a function of echo time (TE). However, short TR is often used to minimize scan time, which may introduce non-negligible errors in T2 measurement. Our study proposed a fast RF-enforced steady state (FRESS) spin echo MRI sequence, which saturates the magnetization after the spin echo and ensures a TE-independent steady state for accurate T2 mapping.