Abstract #4472

Regularized Quantitative Susceptibility Mapping for Phase-Based Regional Oxygen Metabolism (PROM) at 7T

Audrey Peiwen Fan¹, Berkin Bilgic¹, Thomas Benner², Bruce R. Rosen^2,3, Elfar Adalsteinsson^1,3

¹Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; ²Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; ³Health Sciences & Technology, Harvard-MIT, Cambridge, MA, United States

Venous oxygen saturation (Yv) is an important indicator for brain function and absolute quantification of Yv is critical to estimation of the cerebral metabolic rate of oxygen (CMRO2). Here we implement an l₁-regularized quantitative susceptibility mapping technique to measure Yv in cerebral veins at 7T without assumptions about vessel orientation and geometry. QSM measurements in parallel vessel segments resulted in mean Yv = 61.2% and were comparable to mean Yv = 62.1% estimated with MR susceptometry. QSM measurements in curved, in-plane vessel segments resulted in mean Yv = 66.7%, which lies in expected physiological range.