Hye Young Heo1, Brian J. Dlouhy2,
Nader S. Dahdaleh2, Daniel R. Thedens3, Bradley D.
Bolster4, John A. Wemmie2,5, Vincent A. Magnotta1,3
1Biomedical Engineering,
University of Iowa, Iowa City, IA, United States; 2Neurosurgery,
University of Iowa, Iowa City, IA, United States; 3Radiology,
University of Iowa, Iowa City, IA, United States; 4Siemens
Healthcare, Rochester, MN, United States; 5Psychiatry, University
of Iowa, Iowa City, IA, United States
The purpose of this study is to assess the ability of magnetic resonance (MR) imaging to measure relative pH changes in vivo. To evaluate pH changes using T1ρ imaging, T1ρ times were collected for a subject under three conditions: 1) breathing 5% CO2, 2) breathing room air, and 3) hyperventilating. We found that widespread increases in T1ρ times during the 5% CO2 condition were consistent with acidosis, whereas reduced T1ρ times during hyperventilation were consistent with alkalosis.