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Abstract #4509

Tumor Angiogenesis & Vasculature MRI with Endogenous BOLD Effect

Kejia Cai1, Adam Shore1, Anup Singh1, Mohammad Haris1, Damodar Reddy1, Hari Hariharan1, Mark Elliott1, Ravinder Reddy1

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Tumor angiogenesis is the primary facilitator of rapid tumor growth and metastasis. Current MRI techniques using endogenous contrast cannot provide sufficient sensitivity for high-resolution imaging of tumor vasculature. In this study, we use hypoxic challenge to generate sufficient BOLD contrast (~40%), with which high-resolution tumor vasculature maps were able to be obtained. 3D high-resolution tumor vasculature maps can be acquired in minutes. This technique allows us to quantify tumor size, measure tumor vasculature density, provide early detection of tumor metastasis, monitor the effectiveness of cancer treatment drugs, and could potentially characterize tumor grade and aggressiveness.