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Abstract #4513

Quantitative Iron Mapping in Human Brain Based on the Apparent Transverse Relaxation Time

Fumiyuki Mitsumori1, Hidehiro Watanabe1, Nobuhiro Takaya1

1Natl. Inst. Environmental Studies, Tsukuba, Ibaraki, Japan

Iron is an essential element in human body, but its overabundance is toxic through the production of reactive oxygen species. We previously reported that the apparent transverse relaxation rate (R2 = 1/T2) in human brain obtained using a MASE sequence is well explained by a linear combination of the regional non-hemin iron concentration [Fe] and the macromolecular mass fraction fM defined as 1 - water fraction. In the present study we attempted the quantitative iron mapping based on the above relationship between R2, [Fe], and fM. Iron distribution in normal brain and that with cavernous hemangioma was successfully visualized.