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Abstract #4526

Accurate Determination of Water-Macromolecule Exchange Independent of Reference Interaction

Tobias Leutritz1, Liane Hilfert2, Karl-Heinz Smalla3, Oliver Speck1, Kai Zhong1

1Biomedical Magnetic Resonance, Otto-von-Guericke-University, Magdeburg, Germany; 2Institute for Chemistry, Otto-von-Guericke-University, Magdeburg, Germany; 3Leibniz-Institute for Neurobiology, Magdeburg, Germany

Water macromolecule exchange (WME) plays an important role in tissue phase contrast. Previous studies using different NMR references gave different results for WME shift compared to the macromolecule susceptibility shift. Here, a systematic study was carried out and showed that the WME shift is on the same order compared to that of the macromolecule susceptibility shift with opposite sign. The commonly used reference compounds, e.g. trimethyl-silyl-propionate (TMSP) and 1,4-dioxane must be used with caution to obtain proper WME and susceptibility values for tissues.