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Abstract #4556

Fuzzy Partial Volume Correction of Spinal Cord DTI Parameters

Torben Schneider1, David L. Thomas2, Carolina Kachramanoglou2, Olga Ciccarelli2, Daniel C. Alexander3, Claudia A. M. Wheeler-Kingshott1

1Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 3Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom

We present a novel correction method for partial volume effects on the estimation of average parameters derived from diffusion tensor imaging in the cervical spinal cord. We demonstrate improved accuracy of our approach in healthy volunteers and demonstrate that our method significantly reduces bias from partial volume effects.