Abstract #0029

Resting State FMRI Helps to Understand the Pathophysiology of Sensory-Motor & Cognitive Disabilities in MS

Barbara Basile¹,², Maura Castelli³, Fabrizia Monteleone³, Diego Centonze³, Carlo Caltagirone⁴, Marco Bozzali⁵

¹Neuroimaging Laboratory, Santa Lucia Foundation, Rome , Italy, Italy; ²School of Cognitive Psychotherapy, Rome, Italy; ³Neuroscience, University of Rome "Tor Vergata", Rome, Italy; ⁴Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy; ⁵Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

Resting-state fMRI was used here to investigate changes in functional connectivity (FC) within two critical networks, namely the sensory-motor and the default-mode-network, in patients with relapsing-remitting (RR-) and secondary-progressive multiple sclerosis (SPMS). Overall, MS patients compared to healthy controls, revealed a compensatory increase of FC in both networks.