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Abstract #0029

Resting State FMRI Helps to Understand the Pathophysiology of Sensory-Motor & Cognitive Disabilities in MS

Barbara Basile1, 2, Maura Castelli3, Fabrizia Monteleone3, Diego Centonze3, Carlo Caltagirone4, Marco Bozzali5

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome , Italy, Italy; 2School of Cognitive Psychotherapy, Rome, Italy; 3Neuroscience, University of Rome "Tor Vergata", Rome, Italy; 4Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy; 5Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

Resting-state fMRI was used here to investigate changes in functional connectivity (FC) within two critical networks, namely the sensory-motor and the default-mode-network, in patients with relapsing-remitting (RR-) and secondary-progressive multiple sclerosis (SPMS). Overall, MS patients compared to healthy controls, revealed a compensatory increase of FC in both networks.