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Abstract #0042

Multi-Parametric Approach for the Assessment of Tumor Response to Chemotherapy in Locally Advanced Breast Cancer (LABC) Patients: Sequential MRI, DWI & In-Vivo MRS Study

Naranamangalam Raghunathan Jagannathan1, Rani G. Sah1, Uma Sharma1, Rajinder Parshad2, Vurthaluru Seenu2

1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India

Sequential MRI and MRS before therapy and after I, II and neo-adjuvant chemotherapy (NACT) was carried out in 41 breast cancer patients to evaluate the potential of total choline (tCho), ADC and tumor volume to predict tumor response. Our data revealed significant decrease in tCho and ADC after I NACT compared to pre-therapy in responders compared to non-responders. Percentage reduction in tCho was significantly higher compared to ADC and volume in responders after I NACT, which demonstrated early change in metabolic activity compared to structural changes. The combined specificity of all the 3 parameters was higher than the individual parameter.