Elias Kellner1, Irina Mader2, Daniel Nico Splitthoff1, Marco Reisert1, Katharina Frster3, Thao Nguyen-Thanh2, Peter Gall4, Valerij G. Kiselev1
1Department of Radiology, Medical Physics, University Medical Center Freiburg, D-79106 Freiburg, Germany; 2Section of Neuroradiology, Neurocenter of the Freiburg University Hospital, D-79106 Freiburg, Germany; 3Department of Cardiovascular Surgery, Albert-Ludwigs-University Freiburg, D-79106 Freiburg, Germany; 4Department of Radiology, Medical Physics,, University Medical Center Freiburg, D-79106 Freiburg, Germany
Dynamic susceptibility contrast MRI is a well-known method for determination of perfusion parameters in the brain. The major challenge of the method is to measure the contrast inflow into the brain, commonly, the arterial input function (AIF). The measurement of the AIF is subject to a number of problems such as signal void in blood, nonlinear dependence on contrast agent concentration and partial volume effects. In this study, those problems are solved with an extension of a conventional perfusion pulse sequence. Results obtained in an animal model reproduce known values of the cardiac output and the cerebral blood volume.