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Abstract #0093

Assessment of Microstructural White Matter Changes During Early Development with Non-Gaussian Diffusion MRI

MAGNA25Els Fieremans1, Vitria Adisetiyo1, Amir Paydar1, Hetal Sheth1, John Nwankwo1, Jens H. Jensen, 12, Sarah Milla1

1Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, NY, United States; 2Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States

White matter microstructural changes during the first two years of healthy brain development are characterized in terms of non-Gaussian diffusional kurtosis imaging (DKI) parameters. The observed significant non-linear age-related changes in the DKI-parameters suggest an increased sensitivity to brain maturation as compared to standard Gaussian diffusion tensor imaging (DTI). In addition, specific measures of white matter integrity can be derived from DKI, of which significant age-related changes were detected for the axonal water fraction and tortuosity, both markers for myelination, while the intracellular and extracellular diffusivities do not change appreciably in normal brain development.