Abstract #0123

Disrupted White-Matter Structural Networks in Attention Deficit Hyperactivity Disorder

Ni Shu¹, Qingjiu Cao², Li Sun², Li An², Peng Wang², Jinhui Wang³, Mingrui Xia³, Yufeng Wang², Yong He³

¹State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University , Beijing, China; ²Institute of Mental Health, Peking University, Beijing, China; ³State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

In this study, we used diffusion tensor imaging and graph theoretical approaches to investigate the whole-brain white-matter connectional architecture in ADHD patients. We found disrupted topological organization of whiteCmatter structural networks in ADHD patients. Both decreased and increased connections in the patients were mainly located in the frontal regions, insula and striatum structures, providing evidence for the hypothesis of abnormal fronto-striatal-insular circuitry in ADHD. Specifically, the disrupted connections in the fronto-insular component were associated with the inattention performances in patients, improving our understanding of the potential mechanisms underlying the behavior deficits in patients with ADHD.