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Abstract #0160

Simultaneous Acquisition of Quantitative ASL & T2* (SQUAB) for Characterization of Skeletal Muscle Hemodynamics.

Ronn P. Walvick1, Ruth P. Lim1, Vivian S. Lee2

1Radiology, New York University Langone Medical Center, New York, NY, United States; 2The University of Utah, Salt Lake City, UT, United States

BOLD and perfusion change rapidly in skeletal muscle following exercise. In this work, we propose a sequence that allows for simultaneous quantification of T2* and ASL using a sequence featuring dual-echo EPI readouts, and saturation prepared FAIR prepulses for blood labeling. This sequence was tested in a cohort of volunteers and a patient with peripheral arterial disease. We show considerable increases in T2*and blood flow from baseline following exercise in volunteers and a blunted, delayed patient response. Our results show the feasibility of quickly acquiring simultaneous blood flow and T2* data and demonstrate sensitivity to disease