Nai-Wei Yao1, 2, Chiao-Chi V. Chen1, Yi-Hua Hsu1, Hsiu-Ting Lin1, Jeou-Yuan Chen1, Chen Chang1
1Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan; 2Department of Zoology, National Taiwan University, Taipei, Taiwan
Gliomas are aggressive brain tumors with a poor prognosis and remain refractory to treatment. Osteopontin (OPN) is strongly expressed in high-grade and metastatic brain tumors and plays a major role in cancer progression. It is hypothesized in this study that OPN is associated with tumor malignancy. OPN knockdown of rat C6 glioblastoma cells was used as a tactic to investigate the roles of OPN in tumor malignancy. The present study demonstrates that the tumor with OPN-knockdown exhibited lower malignancy than control tumors, including decreased T2 signal intensity of tumor, lower vascular permeability, and the changes of tumor-related metabolites.