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Abstract #0190

Precise Ex-Vivo Histological Validation of Heightened Cellularity in Regions of Dark ADC in Three Cases of High-Grade Glioma

MAGNA25Peter S. LaViolette1, Elizabeth J. Cochran2, Alex D. Cohen3, Mona Al-Gizawiy1, Scott D. Rand, Jennifer Connelly4, Mark G. Malkin5, Wade M. Mueller6, Kathleen M. Schmainda7

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 2Pathology, Medical College of Wisconsin, Milwaukee, WI, United States; 3Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 4Neurology, Medical College of Wisconsin; 5Neurology & Neurosurgery, Medical College of Wisconsin; 6Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; 7Radiology and Biophysics, Medical College of Wisconsin


AFMM (ADC FLAIR MisMatch) is defined as an area of low ADC within FLAIR abnormality associated with a brain tumor. The aim of this study is to determine if areas of AFMM represent increased cellularity by histologic analysis of spatially-correlated ex-vivo issue acquired and processed in three patients with high grade gliomas.

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