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Abstract #0192

Correlations Between PET & DTI Data in Newly Diagnosed GBM Patients Receiving Cediranib Scanned on a Hybrid PET/MR Scanner

Bjorn Stemkens1, 2, Summer Fakhro2, Daniel B. Chonde2, Marco C. Pinho2, Pavlina Polaskova2, Dominique L. Jennings2, Kyrre E. Emblem2, Elizabeth R. Gerstner3, Tracy T. Batchelor3, Ciprian Catana2

1Department of Biomedical Engineering, University of Technology Eindhoven, Eindhoven, Netherlands; 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States; 3Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, United States

Diffusion tensor imaging (DTI) and positron emission tomography (PET) are both imaging techniques that are able to provide information about tumor cellularity and infiltration in the peritumoral region. The purpose is to observe their response in glioblastoma treatment with anti-angiogenic drugs. PET and DTI data are collected simultaneously and baseline measurements are compared to day one after treatment onset. Significant negative correlations were found between mean standard uptake values (SUV) and fractional anisotropy (FA) in the peritumoral region. This implies that metabolic changes correlate with white matter directional changes.