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Abstract #0254

Prognostic Significance of Combined Diffusion Weighted Imaging & Magnetic Resonance Spectroscopy in Neonates with Hypoxic Ischemic Injury

Eva-Maria Ratai1, Jason M. Johnson2, Bindu Setty2, Joseph Chou3, Kalpathy Krishnamoorthy4, Paul Caruso2, P Ellen Grant5

1Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital , Charlestown, MA, United States; 2Radiology, Massachusetts General Hospital, United States; 3Pediatric Medical Services / Neonatal ICU, Massachusetts General Hospital, United States; 4Pediatric Neurology, Massachusetts General Hospital, United States; 5Radiology, Childrens Hospital Boston, United States

The goal of this study was to investigate the prognostic values of ADC and MRS in neonatal hypoxic ischemic injury within 5 days of life. Eight of 17 patients died before discharge from the hospital and nine had unfavorable outcome including severe developmental delay. Low concentrations of N-acetylaspartate, choline, creatine and low ADC values in the basal ganglia were predictive of poor outcome. High glutamate/glutamine levels were also associated with poor outcome. Spearman Rank analysis between ADC and spectroscopic markers revealed significant correlations between ADC and choline as well as ADC and N-Acetylaspartate. No correlation with lactate was found.