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Abstract #0261

Free Breathing Liver DWI Using PROPELLER-DW-EPI with Inherent Reductions of Geometric Distortion & Motion Artifacts at 1.5T

Hing-Chiu Chang1, 2, Nan-Kuei Chen3, Chun-Jung Juan4, Tzu-Chao Chuang5, Cheng-Wen Ko6, Hsiao-Wen Chung2, 4

1Global Applied Science Laboratory, GE Healthcare, Taipei, Taiwan; 2Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 3Brain Imaging and Analysis Center, Duke University, North Carolina, United States; 4Department of Radiology, Tri-Service General Hospital, Taiwan; 5Electrical Engineering, National Sun Yat-sen University, Taiwan; 6Department of Computer Science and Engineering, National Sun Yat-Sen University, Taiwan

Quantitative ADC measurement in liver has been shown to facilitate differential diagnosis of simple versus hydatid cyst. The consequent changes in repetition time of respiratory gating DW-EPI may lead to bias in ADC quantification, especially for long T1 hepatic cyst. The aim of this study is to demonstrate a free breathing ADC measurement method using PROPELLER-DW-EPI. The removal of oblique N/2 ghost prior to PROPELLER reconstruction was accomplished using reference-based and the other reference-free (2D phase-cycled reconstruction) methods, with their results compared. Our preliminary result demonstrates that free breathing PROPELLER-DW-EPI is an attractive alternative for precise ADC measurements in liver.