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Abstract #0303

Long-Term Dosage Effects in Iron Repletion Treatment on Neurochemical Profiles & Gene Expression in Rat Model of Neonatal Iron Deficiency

Ivan Tkac1, Katie Czerniak2, Amy Hurst3, Barbara Felt3, Michael K. Georgieff2, Raghavendra Rao2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Pediatrics, University of Minnesota, Minneapols, MN, United States; 3Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States

In Vivo 1H NMR spectroscopy and qPCR method were used to investigate long-term effect of two different iron repletion therapy protocols on neurochemical profiles and gene expression in prefrontal cortex and hippocampus of neonatally iron deficient rats at adulthood. Region specific differences in NAA, NAAG, PE and GPC+PC were in agreement with observed gene expression. Observed dose-dependent effects of iron repletion protocol potentially may be helpful in optimizing therapy for neonatal iron deficiency.