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Abstract #0331

Slab-Selective, BOLD-Corrected VASO (SS-VASO) in Human Brain at 7T

Laurentius Huber1, Dimo Ivanov1, Markus Streicher1, Robert Turner1

1Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

To understand human brain neural activity it is helpful to study direct physiological variables, such as cerebral blood volume (CBV). Vascular space occupancy (VASO) is a non-invasive fMRI method that measures change in CBV. VASO at 7 T is limited by low signal and BOLD contamination. Here we present a slab-selective, BOLD-corrected SS-VASO variant that avoids these problems, and provides reliable CBV changes in vivo with high sensitivity. Temporal and spatial properties of BOLD and VASO signal are directly compared.