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Abstract #0394

Cardiac Lipids Show Diurnal Variations: An In-Vivo 1H-MR Spectroscopy Study in Humans

Michael Ith1, Christoph Stettler2, Jian Xu3, Chris Boesch4, Roland Kreis4

1University Institute of Diagnostic Interventional and Pediatric Radiology, University & Inselspital Bern, Bern, Switzerland; 2Division of Endocrinology, Diabetes & Clinical Nutrition, University & Inselspital Bern, Bern, Switzerland; 3Siemens Medical Solutions USA, New York, NY, United States; 4Depts Clinical Research and Radiology, University Bern, Bern, Switzerland

In-vivo 1H-MRS was used to measure cardiac lipids (ICCL). The goal of the study was to investigate methodological reproducibility as well as diurnal variations. Nine volunteers were studied three times on one day and two times on another day separated by 1-2weeks to determine short- and long-term-reproducibility, as well as changes between morning and evening. Data analysis revealed a highly significant decrease of ICCL/Cr during the day, whereas ICCL/Cr and TMA/Cr remained stable on repeated measurements. Methodological reproducibility was excellent for all metabolites (CV10%). Long-term variations were in the same range for TMA/Cr but substantially larger for ICCL/Cr.