Abstract #0398

Complex & Magnitude MRI for Quantification of Hepatic Steatosis Correlation with MR Spectroscopy & Biopsy

Alejandro Roldn-Alzate¹, Catherine Hines,¹², Rashmi M. Agni³, Diego Hernando¹, Karl K. Vigen¹,⁴, Gavin Hamilton⁵, Mark Bydder⁵, Claude Sirlin⁵, Scott B. Reeder¹,⁴

¹Radiology, University of Wisconsin, Madison, WI, United States; ²MERK; ³Department of Pathology, University of Wisconsin - Madison, Madison, WI, United States; ⁴Medical Physics, University of Wisconsin, Madison, WI, United States; ⁵University of California San Diego

Synopsis (100 words maximum): NAFLD is the most common type of chronic liver disease affecting an estimated 90-100 million people in the US alone, including 10% of children. Liver biopsy is the current gold standard for diagnosis of NAFLD, but is limited due to sampling variability, cost and risk. The purpose of this study is to validate two quantitative MRI methods (complex, magnitude) for accurate diagnosis and grading of NAFLD using MRI. Single voxel MR spectroscopy and non-targeted liver biopsy are used as reference standards in this study. Excellent correlation between both MRI methods and MRS, and very good correlation with biopsy was found.