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Abstract #0405

Noninvasive Liver Stiffness Assessment with Tagged MRI in Cirrhotic Patients with Child-Pugh Scores

MAGNA25Sohae Chung1, Kyung-Eun Kim2, Mi-Suk Park2, Leon Axel1

1Center for Biomedical Imaging, Radiology Department, NYU Langone Medical Center, New York, NY, United States; 2Department of Diagnostic Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

Liver fibrosis is an important prognostic factor in patients with liver disease, and its assessment can be used to guide therapy. It is known to result in increased mechanical stiffness, so that the assessment of liver stiffness is a key feature of current noninvasive approaches, for example, by detecting the motion of the liver with ultrasound or MRI. In our previous study, we described a new noninvasive approach for the assessment of liver stiffness by using magnetization-tagged MRI (tMRI) to measure the cardiac-induced motion and deformation in the liver. In this work, we applied our method to 45 cirrhotic patients with Child-Pugh scores.