Abstract #0412

The Contribution of Myelin to Magnetic Susceptibility-Weighted Contrasts in High-Field MRI of the Brain

Jongho Lee¹, Karin Shmueli², B-T Kang, Bing Yao², Masaki Fukunaga³, Peter van Gelderen², Sara Palumbo⁴, Francesca Bosetti⁴, Afonso Silva, Jeff Duyn²

¹University of Pennsylvania, Philadelphia, PA, United States; ²AMRI, LFMI, NINDS, NIH; ³Osaka University; ⁴NIA, NIH

In this study, the contribution of myelin to both T2* and frequency contrasts is investigated using a mouse model of cuprizone-induced demyelination. The demyelinated brains showed significantly increased T2* in white matter and a substantial reduction in gray-white matter frequency contrast, suggesting that myelin is a primary source for these contrasts.