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Abstract #0412

The Contribution of Myelin to Magnetic Susceptibility-Weighted Contrasts in High-Field MRI of the Brain

Jongho Lee1, Karin Shmueli2, B-T Kang, Bing Yao2, Masaki Fukunaga3, Peter van Gelderen2, Sara Palumbo4, Francesca Bosetti4, Afonso Silva, Jeff Duyn2

1University of Pennsylvania, Philadelphia, PA, United States; 2AMRI, LFMI, NINDS, NIH; 3Osaka University; 4NIA, NIH

In this study, the contribution of myelin to both T2* and frequency contrasts is investigated using a mouse model of cuprizone-induced demyelination. The demyelinated brains showed significantly increased T2* in white matter and a substantial reduction in gray-white matter frequency contrast, suggesting that myelin is a primary source for these contrasts.