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Abstract #0422

B0-Orientation Dependence Can Characterize Cortical & Sub-Cortical Fibers in vivo at 7T

MAGNA25Julien Cohen-Adad1, Jonathan R. Polimeni1, Bruce R. Rosen1, Caterina Mainero1, Lawrence L. Wald1, 2

1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 2Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States

Recent studies have shown a dependency between T2* and orientation of white matter fibers with respect to the orientation of the main magnetic field B0. Here we demonstrate from in vivo T2* mapping at 7T data that B0-orientation dependence can probe the coherency and orientation of cortical fibers, shedding light into the potential use of this type of contrast to characterize cyto-/myeloarchitecture in vivo. The B0-orientation dependence of sub-cortical fibers revealed consistent anatomical features, reflecting U-fibers running tangentially to the sulci and penetrating radially in both contiguous gyri.