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Abstract #0425

Visualization of the Human Basal Ganglia & Thalamic Circuits in Individuals Using 7T MRI

Christophe Lenglet1, Aviva Abosch2, Essa Yacoub1, Federico De Martino3, Guillermo Sapiro4, Noam Harel1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States; 3Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands; 4Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States

Basal ganglia circuits are affected in neurological disorders such as Parkinsons disease, essential tremor, dystonia and Tourette syndrome. Subject-specific models of the structural and functional connectivity of these circuits are critical for elucidating the mechanisms of these disorders, and developing new treatments. We present a unique ultra-high-field (7T) MRI and computational protocol designed to generate a comprehensive in vivo model of the structure and connections of the human basal ganglia. Our findings open new avenues of investigation into the movement and neuropsychiatric disorders, in individual human subjects.